Epigenetic variability between constitutive and facultative pigmentation in human skin.
Prof. Desmond Tobin
Applications are invited for a temporary post of a UCD Post-doctoral Research Fellow Level 1 or Level 2 within UCD School of Medicine/Charles Institute of Dermatology.
Diversity of human skin colour is regulated at intrinsic (i.e., constitutive) and extrinsic (i.e., facultative) levels. The former refers to an individual’s genetically-determined amount/type of melanin, while the latter refers to the sensitivity/propensity of our skin to respond to stimulated pigmentation (e.g., from hormones, UVR etc.). Importantly, human skin phototypes reflect relative activity, rather than absolute number, of melanocytes.
As an interface tissue, human skin is subjected to a wide range of stimuli, some of which induce stable, reversible and/or heritable, changes in how genes function, in a way that does not result in DNA sequence change. Our knowledge of such ‘epigenetic’ control of pigmentation in human skin is still in its infancy and is the focus of this project. We will ask if epigenetic regulation of human skin pigmentation at baseline is similar or different to stimulated pigmentation, and if different, whether differential regulation is influenced by particular epigenetic events.
This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.
PD1 Salary: €39,522 - €45,610 per annum
PD2 Salary: €46,906 -€48,242 per annum
Appointment on the above range will be dependent upon qualifications and experience.
Closing date: 17:00hrs (local Irish time) on the 11th of May 2022.
Identifying epigenetic vulnerability in childhood blood cancers.
Prof. Jonathan Bond
We are accepting applications for a three-year post-doctoral position under the Precision Oncology Ireland (POI) programme (https://www.precisiononcology.ie/), to be supervised by Prof. Jonathan Bond (Systems Biology Ireland, UCD and Children’s Health Ireland at Crumlin).
The aim of the project is to discover molecular vulnerabilities in high-risk childhood blood cancers using a combination of high-throughput approaches, including CRISPR/Cas9 screening. Promising therapeutic strategies will then be tested both in vitro and in vivo in mouse models of leukaemia.
The successful applicant will be part of the growing Childhood and Adolescent Leukaemia multidisciplinary research team that is based at Systems Biology Ireland and closely integrated with the clinical Irish National Children’s Cancer Service at CHI at Crumlin, and will work closely with another post-doctoral scientist employed as part of the POI research programme.
Salary will be based on the SFI pay scales for early post-doctoral researchers (€ 38,631- € 44,658 per annum, depending on prior experience).
Prospective applicants should apply through the UCD HR website (https://www.ucd.ie/workatucd/jobs/ search for post number 014106). Informal enquiries can be made directly to Prof. Bond at firstname.lastname@example.org.